For titanium, Inconel, hardened steels and other tough materials, rigidity and coolant win over speed. The best machine is a stiff, heavy machining center or turning center with strong low-end spindle torque, high-pressure (through-spindle) coolant and a solid control — box ways or heavy linear guides help damp the cut.
Above ~45 HRC, hard turning, grinding or EDM may replace conventional cutting. Match the machine to the material and value it right at The Machine Blue Book.
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