Impellers, blisks and turbine blades are the classic case for simultaneous 5-axis machining: deep, twisted, overlapping blades that a 3-axis machine simply can't reach, cut in one setup for accuracy and surface quality. In titanium and nickel alloys they also demand rigidity, high-pressure coolant and strong CAM with collision avoidance.
This is 5-axis territory, full stop, often in tough materials. See titanium and Inconel machining, and value 5-axis machines at The Machine Blue Book.
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