The CNC control is the machine's brain and language. The main platforms differ in how you program them, who supports them, and how they affect resale.
Fanuc
The global baseline — the most widely used control, easiest to staff and support, standard G-code. Broad service network and strong resale.
Mazatrol
Mazak's conversational control: program many parts on the machine through prompts instead of raw G-code. Tightly integrated with Mazak machines (can also run ISO G-code).
Siemens Sinumerik
Common on European and high-end 5-axis machines; powerful multi-axis and high-speed features with its own programming environment.
Bottom line
Fanuc for ubiquity and support, Mazatrol for fast shop-floor programming on Mazak iron, Siemens for high-end European and 5-axis work. Okuma's OSP is a fourth, machine-integrated option. The control your people know should weigh heavily in a buy.